Ph.D. Candidate & Graduate Researcher

The petitioner proposes to continue research in structural biology and drug discovery, specifically focusing on the three-dimensional structures of human membrane proteins linked to rare diseases. This work involves using cryo-electron microscopy and mammalian host cells to identify critical features for developing innovative antibodies and small-molecule inhibitors. The goal is to advance targeted treatment strategies for infectious diseases, cancer, and rare conditions.

The petitioner proposes to advance computational algorithms and experimental screening techniques to streamline the creation of modular, low-cost, and efficient protein therapeutics. This work focuses on improving the stability and production of drugs like antibodies and insulins to eliminate cold-chain transportation barriers and reduce healthcare costs.

The petitioner proposes to continue research evaluating how changes in RNA impact protein synthesis and influence the progression of health burdens including cancer, aging, and infectious diseases. He utilizes expertise in RNA folding, ribosome assembly, and protein synthesis mechanisms to identify novel therapeutic targets for these disorders.

The petitioner proposes to continue her research in molecular biology, specifically focusing on identifying drug targets and their mechanisms of action in complex biological samples. Her work utilizes proteogenomic approaches to elucidate the relationship between genetic mutations and protein functions in breast cancer. This research is intended to enhance the understanding of disease mechanisms and inform the development of targeted therapies for cancer, metabolic disorders, and neurodegenerative conditions.